Vol 14, Issue 3

Combined Physical Training Increases Plasma Brain-Derived Neurotropic Factor Levels, But Not Irisin in People Living with HIV/AIDS

April 1, 2021 - By 

Authors

Joice Cristina dos Santos Trombeta, University of Campinas
Roberto Carlos Vieira Junior
Cláudia Regina Cavaglieri
Ivan Luiz Padilha Bonfante, University of Campinas
Jonato Prestes
Ramirez Alsamir Tibana
Morteza Ghayomzadeh
Vinicius Carolino Souza
Seyedahmad Seyedalinaghi
James Wilfred Navalta, University of Nevada
Fabrício Azevedo Voltarelli, Federal University of Mato Grosso
International Journal of Exercise Science 14(3): 1004-1017, 2021.
DOI: 10.70252/HOMO5275

Abstract

This study evaluated plasma levels of brain-derived neurotropic factor (BDNF), irisin, and lactate in people living with HIV/AIDS who completed a combined physical training program. Nineteen HIV+ participants (age: 39.60 ± 10.96 years; carrier time: 7.75 ± 7.88 years; time of ART: 6.41 ± 5.93 years) performed strength/aerobic training (combined physical training) in the same session for 8 weeks and levels of BDNF, irisin, and lactate were assessed. BDNF (pg/mL) was higher post-CPT (Pre: 1258.73 ± 372.30; Post: 1504.17 ± 322.30; p < 0.001). Irisin (ng/mL) showed no change (Pre: 115.61 ± 72.41; Post: 125.87 ± 81.14; p = 0.973). There was positive correlation between irisin and lactate (mmol/L) pre (r = 0.55, p = 0.04), and lactate values were higher in the group with the highest value of irisin (3.65 ± 0.69 x 2.82 ± 0.59, p = 0.02). Combined physical training results in increased basal BDNF in people living with HIV/AIDS, this finding suggests that increased concentration of BDNF may be associated with decreased chances of developing cognitive disorders or HIV-associated dementia. Further studies involving molecular mechanisms on this subject are necessary.

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