Vol 17, Issue 2

Acute Effects of Serial and Integrated Concurrent Exercise on Circulating MicroRNAs -126 and -222 in Sedentary Adults

February 15, 2024 - By 

Authors

Matthew F. Brisebois, University of South Carolina Upstate
Ryan A. Gordon, Missouri State University
Emily L. Zumbro, University Of Alabama At Birmingham
Matthew L. Sokoloski, Texas Woman’s University
Anthony A. Duplanty, Texas Woman’s University
Shanil Juma, Texas Woman’s University
Brandon R. Rigby, Texas Woman’s University
International Journal of Exercise Science 17(2): 1444-1460, 2024. 
DOI:10.70252/XFJK8005

Abstract

The purpose of this study was to compare changes in circulating microRNAs -126 (c-miR-126) and -222 (c-miR-222) following acute serial concurrent exercise (SCE) and integrated concurrent exercise (ICE) sessions among young, sedentary adults. Ten males and 9 females completed the study procedures. For SCE, participants performed resistance exercise (RE) followed by aerobic exercise (AE), without mixing the two. For ICE, participants performed a brief bout of AE before each set of RE. Blood was collected before, immediately after (IP), and 1 h (1HR) after each exercise session. Expression of c-miR-126 significantly increased from baseline at IP (1.6-fold SCE, 2.1-fold ICE; p = .037) and 1HR (1.8-fold SCE, 1.7-fold ICE; p = .034) following both sessions, with no difference between the two sessions. Expression of c-miR-222 significantly increased from baseline at IP (1.7-fold SCE, 1.9-fold ICE; p = .024) and 1HR (2.0-fold SCE, 1.6-fold ICE; p = .038) following both sessions, with no difference between the two sessions. There were no differences in peak heart rate or average heart rate between the two workout sessions. Both SCE and ICE patterns appear equally effective at acutely increasing c-miR-126 and -222.

Recommended Citation