Authors
Monica Dwi Jalma, Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Imelda Rosalyn Sianipar, [1]Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, [2]Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Roman Ardian Goenarjo, [1]Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, [2]Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Nurul Paramita, [1]Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, [2]Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Dewi Irawati Soeria Santoso, [1]Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, [2]Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
International Journal of Exercise Science 19(2): 1-12, 2026.
DOI: 10.70252/IJES2026204
Abstract
Hypertension remains a major global health burden, yet the optimal exercise strategy to mitigate its associated inflammatory and oxidative stress responses is still unclear. This study aimed to compare the effects of high- intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on markers of inflammation and oxidative stress, including serum IL-6, NOX4, and cardiac tissue MMP-2 in a rat model of hypertension. Hypertension was induced in male Wistar rats through L-NAME administration for five weeks, during which the rats concurrently underwent HIIT or MICT. L-NAME administration resulted in a progressive increase in systolic blood pressure (SBP) by week five compared to control rats. L-NAME significantly increased serum IL-6 and NOX4 levels but did not significantly affect cardiac MMP-2 expression. MICT significantly reduced SBP and NOX4 levels, whereas IL-6 and MMP-2 levels remained unchanged. In contrast, HIIT did not produce significant reductions in SBP, IL-6, NOX4, or MMP-2. Statistical significance was defined as p ≤ 0.05. In conclusion, these findings indicate that MICT is more effective than HIIT in reducing elevated SBP and NOX4 levels in L-NAME-induced hypertensive rats.
Recommended Citation
Jalma, Monica Dwi; Sianipar, Imelda Rosalyn; Goenarjo, Roman Ardian; Paramita, Nurul; Santoso, Dewi Irawati Soeria (2026) “HIIT versus MICT on Blood Pressure and Cardiac Biomarkers in L-NAME- induced Hypertensive Rats,” International Journal of Exercise Science: Vol. 19 : Iss. 2, Pages 1-12.
DOI: https://doi.org/10.70252/IJES2026204